O. Kölln and H. Redlich, Synthesis, 1995, 1995, 1383–1388.
Wednesday, April 4, 2018
Thursday, March 2, 2017
Zeta potential - wiki
Zeta potential is a scientific term for electrokinetic potential in colloidaldispersions. In the colloidal chemistry literature, it is usually denoted using the Greek letter zeta (ζ), hence ζ-potential. From a theoretical viewpoint, the zeta potential is the electric potential in the interfacial double layer (DL) at the location of the slipping plane relative to a point in the bulk fluid away from the interface.
Further reading:
Further reading:
Density Functional Theory (DFT) - wiki
Density functional theory (DFT) is a computational quantum mechanical modelling method used in physics, chemistry and materials science to investigate the electronic structure (principally the ground state) of many-body systems, in particular atoms, molecules, and the condensed phases.
Further reading:
Further reading:
Monday, February 13, 2017
Hit to lead (H2L) - wiki
Hit to lead (H2L) also known as lead generation is a stage in early drug discovery where small molecule hits from a high throughput screen (HTS) are evaluated and undergo limited optimization to identify promising lead compounds.[1][2] These lead compounds undergo more extensive optimization in a subsequent step of drug discovery called lead optimization (LO).[3][4] The drug discovery process generally follows the following path that includes a hit to lead stage:
- target validation (TV) → assay development → high-throughput screening → hit to lead (H2L) → lead optimization (LO) → preclinical drug development → clinical drug development
Further reading:
Abamectin - wiki
Abamectin is a widely used insecticide and anthelmintic.
Abamectin is a mixture of avermectins containing more than 80% avermectin B1a and less than 20% avermectin B1b. These two components, B1a and B1b have very similar biological and toxicological properties. The avermectins are insecticidal and antihelmintic compounds derived from various laboratory broths fermented by the soil bacterium Streptomyces avermitilis. Abamectin is a natural fermentation product of this bacterium.
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The Morita-Baylis-Hilman reaction - wiki
The Baylis–Hillman reaction is a carbon-carbon bond forming reaction between the α-position of an activated alkene and an aldehyde, or generally a carbon electrophile. Employing a nucleophilic catalyst, such as tertiary amine and phosphine, this reaction provides a densely functionalized product (e.g. functionalized allyl alcohol in the case of aldehyde as the electrophile). This reaction is also known as the Morita–Baylis–Hillman reaction or MBH reaction. It is named for the Japanese chemist Ken-ichi Morita, the British chemist Anthony B. Baylis and the German chemist Melville E. D. Hillman.
Links:
http://www.organic-chemistry.org/namedreactions/baylis-hillman-reaction.shtm
http://www.name-reaction.com/baylis-hillman-reaction
http://www.name-reaction.com/baylis-hillman-reaction
Further reading:
Tuesday, January 24, 2017
MRSA - wiki
Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterium responsible for several difficult-to-treat infections in humans. MRSA is any strain of Staphylococcus aureus that has developed, through horizontal gene transfer and natural selection, multi- resistance to beta-lactam antibiotics, which include the penicillins (methicillin, dicloxacillin, nafcillin, oxacillin, etc.) and the cephalosporins. MRSA evolved from horizontal gene transfer of the mecA gene to at least five distinct S. aureus lineages
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