Acetylide ions are very useful in organic chemistry reactions in combining carbon chains, particularlyaddition reactions. One type of reaction displayed by acetylides are nucleophilic addition reactions withketones to form α-alkynyl alcohols.
Several modifications of alkynation reactions are known:
- In the Arens–van Dorp Synthesis the compound ethoxyacetylene is converted to an Grignard reagent and reacted with a ketone, the reaction product is a propargyl alcohol.
- The Isler modification is a modification of Arens–van Dorp Synthesis where ethoxyacetylene is replaced by β-chlorovinyl ether and lithium amide.
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