Monday, February 13, 2017

The Morita-Baylis-Hilman reaction - wiki

The Baylis–Hillman reaction is a carbon-carbon bond forming reaction between the α-position of an activated alkene and an aldehyde, or generally a carbon electrophile. Employing a nucleophilic catalyst, such as tertiary amine and phosphine, this reaction provides a densely functionalized product (e.g. functionalized allyl alcohol in the case of aldehyde as the electrophile). This reaction is also known as the Morita–Baylis–Hillman reaction or MBH reaction. It is named for the Japanese chemist Ken-ichi Morita, the British chemist Anthony B. Baylis and the German chemist Melville E. D. Hillman.





Links:

Further reading:

The Catalyzed α‐Hydroxyalkylation and α‐Aminoalkylation of Activated Olefins (The MoritaBaylisHillman Reaction)

The enantioselective MoritaBaylisHillman reaction and its aza counterpart


Asymmetric Morita− Baylis− Hillman Reactions Catalyzed by Chiral Brønsted Acids








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