Monday, May 16, 2016

Aldol addition - wiki

A generalized view of the Aldol reaction
A generalized view of the Aldol reaction (Photo credit: Wikipedia)
The aldol reaction is a means of forming carbon–carbon bonds inorganic chemistry. Discovered independently by Charles-Adolphe Wurtz and Alexander Borodin in 1872, the reaction combines two carbonyl compounds (the original experiments used aldehydes) to form a new β-hydroxy carbonyl compound. These products are known as aldols, from the aldehyde + alcohol, a structural motif seen in many of the products. Aldol structural units are found in many important molecules, whether naturally occurring or synthetic. For example, the aldol reaction has been used in the large-scale production of the commodity chemicalpentaerythritol and the synthesis of the heart disease drug Lipitor (atorvastatin, calcium salt).





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