The Michaelis–Arbuzov reaction (also called the Arbuzov reaction) is the chemical reaction of a trialkyl phosphite and an alkyl halide to form aphosphonate.
The reaction was discovered by August Michaelis in 1898, and greatly explored by Aleksandr Arbuzov soon thereafter. This reaction is widely used for the synthesis of various phosphonates, phosphinates, andphosphine oxides. Several reviews have been published. The reaction also occurs for coordinated phosphite ligands, as illustrated by the demethylation of {(C5H5)Co[(CH3O)3P]3}2+ to give {(C5H5)Co[(CH3O)2PO]3}−, which is called the Klaui ligand.
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