Monday, May 16, 2016

Algar–Flynn–Oyamada reaction - wiki

The Algar–Flynn–Oyamada reaction is a chemical reaction whereby a chalcone undergoes an oxidative cyclization to form a flavonol.

The Algar–Flynn–Oyamada reaction





Flavonols are a class of flavonoids that have the 3-hydroxyflavone backbone. Their diversity stems from the different positions the phenolic -OH groups. They are distinct from flavanols (with "a") such as catechin, another class of flavonoids.





Chalcone is an aromatic ketone and an enone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones or chalconoids.



Flavonols example:

3-Hydroxyflavone is a chemical compound. It is the backbone of all flavonols, a type of flavonoid. It is a synthetic compound, which is not found naturally in plants. It serves as a model molecule as it possesses an excited-state intramolecular proton transfer (ESIPT) effect to serve as a fluorescent probe to study membranes for example or intermembrane proteins. The green tautomer emission (λmax ≈ 524 nm) and blue-violet normal emission (λmax ≈ 400 nm) originate from two different ground state populations of 3HF molecules. The phenomenon also exists in natural flavonols


Quercetin /ˈkwɜːrstn/ is a flavonolfound in many fruits, vegetables, leaves and grains. It can be used as an ingredient in supplements, beverages, or foods.



Further reading:

A modification of the algarflynnoyamadapreparation of flavonols

Aspects of the Algar-Flynn-Oyamada (AFO) reaction

[PDF] 737. The course of theAlgarFlynnOyamada (AFO) reaction

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